One-Pot Consecutive Reductive Amination Synthesis of Pharmaceuticals: From Biobased Glycolaldehyde to Hydroxychloroquine

Reductive amination plays a paramount role in the synthesis of amines. It is often proposed as more ecofriendly process than traditional SN2-type reactions amines it avoids toxic alkylation reagents such alkyl halides. This work demonstrates versatility reductive reaction via hydroxychloroquine (HCQ), one most renowned pharmaceuticals during this coronavirus pandemic. The novel green strategy based on three consecutive conducted one-pot system, avoiding intermediary purification steps. Furthermore, biobased C2 platform molecule, glycolaldehyde, was selected starting reagent. newly developed pathway appraised using CHEM21 Green Metric toolkit and compared with commercially operating method.